RxClass Overview
The RxClass Browser is a web application for exploring and navigating through the class hierarchies to find the RxNorm drug members associated with each class.

The RxClass API is available for users to include RxClass data in their applications.

RxClass links drug classes with several drug sources to their RxNorm drug members (usually ingredients, precise ingredients and multiple ingredients).

RxClass allows users to search by class name or identifier to find the RxNorm drug members or, conversely, search by RxNorm drug name or identifier to find the classes that the RxNorm drug is a member of.

Note: In June 2018, NDF-RT was replaced by MED-RT as a source of drug class relations. Additionally, the VA drug-class relations contained in NDF-RT were replaced by VANDF data.


Class Types

RxClass contains ten drug class trees:

Sources of Drug-Class Relations

There are seven sources which associate generic drugs to the classes listed above.
Note: the three sources - DailyMed, MEDRT and FDASPL - contain overlapping and redundant associations of drugs to some of the class trees (see tables below), so to avoid confusion only one of those sources is selected at any given time in RxClass.

The following table lists the drug sources and the classes they associate with .

Class \ Source ATC    MeSH   DailyMed FDASPL FMTSME MEDRT  VA    
ATC1-4    X
MeSHPA     X
EPC       X      X
Chem       X      X      X
Disease      X
MoA       X      X      X
PE       X      X      X
PK      X
TC      X
VA       X

Relationships to Drug Classes

The following table shows the relationships each drug source uses to identify with the drug class.

Drug Source Relation Drug Class Description
ATC (level 5) ATC1-4 Drug members of an ATC class
MeSH MeshPA Drug members of a MeSH Pharmacologic Action
DailyMed has_EPC EPC Drug members of a FDA Established Pharmacologic Class
DailyMed has_Chemical_Structure Chem Drugs that have a chemical structure
DailyMed has_MoA MoA Drugs that have a Mechanism of Action
DailyMed has_PE PE Drugs that have a Physiologic Effect
FDASPL has_EPC EPC Drug members of a FDA Established Pharmacologic Class
FDASPL has_Chemical_Structure Chem Drugs that have a chemical structure
FDASPL has_MoA MoA Drugs that have a Mechanism of Action
FDASPL has_PE PE Drugs that have a Physiologic Effect
FMTSME has_TC TC Drugs that have Therapeutic Categories
MEDRT CI_ChemClass Chem Drugs that are contraindicated with a chemical class
MEDRT has_ingredient Chem Drugs that are members of a chemical class
MEDRT has_active_metabolites Chem Drugs that have active metabolites in a chemical class
MEDRT CI_with Disease Drugs that are contraindicated with a disease
MEDRT induces Disease Drugs that induce a disease
MEDRT may_diagnose Disease Drugs that may diagnose a disease
MEDRT may_prevent Disease Drugs that may prevent a disease
MEDRT may_treat Disease Drugs that may treat a disease
MEDRT CI_MoA MoA Drugs that are contraindicated with a Mechanism of Action
MEDRT has_MoA MoA Drugs that have a Mechanism of Action
MEDRT CI_PE PE Drugs that are contraindicated with a Physologic Effect
MEDRT has_PE PE Drugs that have a Physiologic Effect
MEDRT has_PK PK Drugs that are members of a Pharmacokinetics Class
MEDRT site_of_metabolism PK Drugs that have a site of metabolism in a Pharmacokinetics Class
VA has_VAClass VA Clinical drugs that are members of a VA Class
VA has_VAClass_extended VA Clinical drugs that are derived members of a VA Class

 
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